高血壓 高尿酸 慢性腎病 胰島素 https://2019medicinenote.blogspot.com/2019/12/blog-post_57.html . 糖尿病相關筆記~目錄 https://2019medicinenote.blogspot.com/2020/01/blog-post_4.html

2023年12月28日 星期四

急性鼻竇炎 -台灣家庭醫學醫學會及uptodate . StatPearls [Internet].

2024-08-09 10:34AM 剛看到ENT醫師寫的文章. 提到急性鼻竇炎標準治療是抗生素.
順手查了一篇2023年8月的paper. 關於急性鼻竇炎定義. 四周內屬於急性. 
而要診斷急性鼻竇炎. 症狀通常持續 10 天以上. 
因此. 一般感冒初期一周. 不開抗生素是合理的. 


google中文翻譯如下(原文在下面, 僅節錄片段)
病毒性鼻竇炎(VRS)
急性細菌性鼻竇炎 (ABRS) 
急性侵襲性真菌性鼻竇炎(IFS)
過敏性真菌性鼻竇炎(AFS)

鼻竇炎可分為以下幾類(更多基於共識而非實證研究)
急性 - 症狀持續少於 4 週
亞急性 - 症狀持續 4 至 12 週
慢性 - 症狀持續超過 12 週
復發 - 四次發作,持續時間不到 4 週,兩次發作之間症狀完全緩解

急性鼻竇炎是一種臨床診斷。臨床醫生最常需要區分 VRS 和 ABRS,這對於確保負責任地使用抗生素至關重要。需要闡明青黴素不敏感肺炎鏈球菌的當地抗藥性模式和盛行率。

成人鼻竇炎的常規診斷標準是患者至少有兩種主要症狀或一種主要症狀加上兩種或多種輕微症狀。兒童的標準相似,只是更注重鼻分泌物(而非鼻塞)。

主要症狀

  • 前鼻流膿性分泌物
  • 後鼻涕膿性或變色
  • 鼻塞或阻塞
  • 臉部充血或飽滿
  • 臉部疼痛或壓力
  • 嗅覺減退或嗅覺喪失
  • 發燒(僅適用於急性鼻竇炎) 

輕微症狀:

  • 頭痛
  • 耳朵疼痛或有壓力或飽脹感
  • 口臭
  • 牙齒疼痛
  • 咳嗽
  • 發燒(亞急性或慢性鼻竇炎)
  • 疲勞

可以使用以下臨床指導將 ABRS 與 VRS 區分開來

  • 症狀持續十天以上
  • 發病時持續 3 至 4 天高燒(超過 39°C 或 102°F),伴隨膿性鼻涕或臉部疼痛
  • 前十天內症狀加倍惡化

一般不需要進行常規實驗室評估。囊性纖維化、纖毛功能障礙或免疫缺陷的評估是頑固性、復發性或慢性鼻竇炎的考慮因素。 有證據顯示 ESR 和 CRP 升高可能與細菌感染有關。

大於或等於 10 CFU/mL 的內視鏡抽吸培養物被視為黃金標準。然而,這對於診斷來說並不是必需的,並且對於絕大多數 ABRS 病例也沒有這樣做。鼻和鼻咽培養物的實用性較低,因為它們與內視鏡抽吸物的相關性較差。轉診內視鏡抽吸對於難治性病例或多種抗生素過敏的患者可能有用。  

除非臨床上擔心併發症或替代診斷,否則沒有必要急性鼻竇炎進行影像學檢查。竇平片通常不能用於檢測發炎。它們可能會顯示空氣-液體水平。然而,這無助於區分病毒與細菌病因。如果懷疑有併發症或替代診斷,或患者反覆出現急性感染,則應進行鼻竇 CT 影像,以評估骨骼、軟組織、牙齒或其他解剖異常或是否有慢性鼻竇炎。這些應該在適當的治療過程結束時獲得。鼻竇 CT 可顯示氣液水平、混濁和發炎。鼻竇黏膜增厚超過 5 毫米則表示有發炎。 它還可以有效評估骨侵蝕或破壞。然而,這些發現也無助於區分病毒與細菌病因。 MRI 比鼻竇 CT 提供更多細節,可以評估軟組織或幫助闡明腫瘤。因此,MRI 可能有助於確定眼眶或顱內擴展等病例的併發症程度。


Evaluation
Acute rhinosinusitis is a clinical diagnosis. The clinician most commonly needs to distinguish between VRS and ABRS, which is crucial to ensure the responsible usage of antibiotics. Local resistance patterns and prevalence of penicillin non-susceptible S. pneumoniae requires elucidation.

Conventional diagnostic criteria for rhinosinusitis in adults is the patient having at least two major or one major plus two or more minor symptoms. The criteria in children are similar except that there is more of an emphasis on nasal discharge (rather than nasal obstruction).Major symptoms:Purulent anterior nasal discharge
Purulent or discolored posterior nasal discharge
Nasal congestion or obstruction
Facial congestion or fullness
Facial pain or pressure
Hyposmia or anosmia
Fever (for acute sinusitis only)

Minor symptoms:Headache
Ear pain or pressure or fullness
Halitosis
Dental pain
Cough
Fever (for subacute or chronic sinusitis)
Fatigue

ABRS can be differentiated from VRS using the following clinical guidance[4][6][1][3]:Duration of symptoms for more than ten days
High fever (over 39 C or 102 F) with purulent nasal discharge or facial pain that last for 3 to 4 consecutive days at the beginning of the illness
Double worsening of symptoms within the first ten days

Routine laboratory assessment is generally not necessary. Evaluation for cystic fibrosis, ciliary dysfunction, or immunodeficiency are considerations for intractable, recurrent, or chronic rhinosinusitis. There is some evidence that an elevated ESR and CRP may be associated with a bacterial infection.

The culture of endoscopic aspirates with greater than or equal to 10 CFU/mL is considered the gold standard. However, this is not necessary for diagnosis and not done for the vast majority of cases of ABRS. Nasal and nasopharyngeal cultures are of low utility due to their poor correlation with endoscopic aspirates. Referral for endoscopic aspiration can be useful for refractory cases or patients with multiple antibiotic allergies.

Imaging for acute sinusitis is not necessary unless there is a clinical concern for a complication or alternative diagnosis. Sinus plain films are generally not useful in detecting inflammation. They may show air-fluid levels. However, this does not help differentiate viral versus bacterial etiologies. If a complication or alternative diagnosis is suspected, or if the patient has recurrent acute infections, then sinus CT imaging should be obtained to assess for bone, soft tissue, dental, or other anatomical abnormalities or the presence of chronic sinusitis. These should be obtained at the end of an appropriate treatment course. Sinus CT may show air-fluid levels, opacification, and inflammation. A thickened sinus mucosa over 5 mm is indicative of inflammation. It can also effectively assess bony erosion or destruction. However, these findings are also not helpful in differentiating viral versus bacterial etiologies. MRI offers more detail than sinus CT to evaluate soft tissue or help elucidate a tumor. Thus, MRI may be helpful to determine the extent of complications in cases such as an orbital or intracranial extension.

2024-05-14 11:45AM
參考資料: 成人急性細菌性鼻竇炎治療指引檔案下載
這篇是刊登於家庭醫學與基層醫療第二十八卷第5期(102 年 5 月 25 日)
雖資料有點陳舊., 不過需修改的地方不多.
(家庭醫學與基層醫療期刊總目錄)











參考資料 Acute sinusitis and rhinosinusitis in adults: Clinical manifestations and diagnosis uptodate
2023-12-29 10:02AM
病毒性鼻竇炎. 症狀通常小於10天.
Acute viral rhinosinusitis — Acute viral rhinosinusitis (AVRS) is diagnosed clinically when patients have <10 days of symptoms consistent with ARS that are not worsening [2].

細菌性鼻竇炎.
Acute bacterial rhinosinusitis — We use the following criteria to diagnose acute bacterial rhinosinusitis (ABRS), which are derived from the American Academy of Otolaryngology-Head and Neck Surgery guidelines and the Infectious Diseases Society of America guidelines [2,16]:


診斷標準(符合其中一項)
1. 症狀持續超過 10 天沒有改善
2. 感冒症狀持續超過十天. 期間症狀改善, 第五六天後又變嚴重.
●Persistent symptoms or signs of ARS lasting 10 or more days without evidence of clinical improvement or

●A biphasic pattern of illness, typically extending over a 10-day period, characterized by signs and symptoms of ARS that initially start to improve but then worsen approximately five to six days later ("double worsening").

嚴重感染症狀. 持續性高燒超過 39°C. 膿狀鼻涕. 顏面疼痛 3-4 天以上
但並非症狀嚴重就需要吃抗生素
The onset of severe symptoms or signs of severe illness (eg, high fever [>39°C or 102°F], purulent nasal discharge, facial pain) for at least three to four consecutive days at the beginning of illness supports the diagnosis of ABRS. However, severity of illness alone is not sufficient criteria for starting antibiotics.

並非每個患者都需要做影像檢查. 鼻腔細菌培養, 鼻竇抽吸,
當懷疑患者發生併發症才需要做.
Imaging, nasal cultures, sinus aspirates, and other microbiologic testing are not indicated for patients with clinically diagnosed uncomplicated AVRS or ABRS [2,16]. These tests are reserved for patients with suspected complications.

Other guidelines use varying criteria to diagnose ABRS. These criteria may be based on specific symptoms or duration of illness [37,38].

2023年12月21日 星期四

[疾管署2023-09-01 ]流感疫苗副作用

2023-12-22 
路徑: 疾管署首頁 >>預防接種 >>疫苗資訊 >>疫苗區Q&A 季節性流感疫苗Q&A 疫苗安全及接種篇

Q27.流感疫苗安全嗎?會有什麼副作用?
今年政府採購4廠牌疫苗皆符合我國衛生福利部食品藥物管理署查驗登記規定,且經其核准使用/進口,安全無虞。

疫苗與其他任何藥品一樣有可能造成副作用,包括接種後可能會有注射部位疼痛、紅腫,少數的人則會有全身性的輕微反應,如:發燒、頭痛、肌肉酸痛、噁心、皮膚搔癢、蕁麻疹或紅疹等,一般會在發生後1-2天內自然恢復。

嚴重的副作用,如立即型過敏反應,甚至過敏性休克等不適情況(臨床表現包括呼吸困難、聲音沙啞、氣喘、眼睛或嘴唇腫脹、頭昏、心跳加速等),發生機率非常低,若不幸發生,通常於接種後幾分鐘至幾小時內即出現症狀。

其他曾被零星報告過之不良事件包括神經系統症狀(如:臂神經叢炎、顏面神經麻痺、熱痙攣、腦脊髓炎、以對稱性神經麻痺為表現的Guillain-Barré症候群等)和血液系統症狀(如:暫時性血小板低下,臨床表現包括皮膚出現紫斑或出血點、出血時不易止血等)。

除了1976年豬流感疫苗、2009年H1N1新型流感疫苗與部分季節性流感疫苗經流行病學研究證實與Guillain-Barré症候群可能相關外,少有確切統計數據證明其他不良事件與接種流感疫苗有關。

最後更新日期2023/9/1




2023年12月13日 星期三

B肝帶原患者肝指數上升評估

2023-12-14 15:10
B肝帶原患者. 肝指數上升需檢測病毒量. 如果少於 2000 iu/mL 需考慮其他原因

肝發炎指數異常!到底要不要緊?
諮詢╱徐士哲(臺大肝膽胃腸科主治醫師)楊培銘(臺大醫學院名譽教授)撰稿╱黃靜宜

即使有B肝帶原,肝發炎指數又異常,也不能斷定就是B肝引起,這時會加驗血中B肝病毒量。如果少於2000 IU/ml,甚至測不到病毒量,就要考慮其他可能性。

C肝治療

2023-12-13
C肝感染之後
7-8 成會變成慢性肝炎.
經過 20-30 年. 有 2-3 成的患者會進展到肝硬化
C肝合併肝硬化. 每年5%會罹患肝癌

C肝病毒抗體陽性. 代表曾經被感染過. 這樣的患者. 約 42~88% 會呈現 HCV RNA 陰性. 亦即體內已經沒有 C肝病毒
參考資料: 國家消除C肝政策綱領 2018~2025 (2019年5月出版)















[疾管署]
急性病毒性C型肝炎防治工作手冊

 附件: 急性病毒性C型肝炎工作手冊.pdf(2019年1月修訂)


[疾管署]急性病毒性C型肝炎核心衛教_1080830修.pdf

C型肝炎病毒急性感染後
約20-30%患者有臨床症狀(發燒、疲倦、厭食、隱約腹部不適、噁心、嘔吐或黃疸等)
 約70%-80%會演變成慢性肝炎,在慢性C型肝炎患者中,約5-20%於20-30年間可能演變為肝硬化,約1-5%死於慢性肝炎的併發症。
 目前無C型肝炎疫苗。

Hepatitis C and hepatocellular carcinoma
Among patients with hepatitis C and cirrhosis, the annual incidence rate of HCC ranges between 1-8%, being higher in Japan (4-8%) intermediate in Italy (2-4%) and lower in USA (1.4%).

[2012-04-15]C肝者罹肝癌風險 6指標預知
在台灣約有40~60萬人是C型肝炎患者。感染C型肝炎後,約七~八成的人會變成慢性C型肝炎;這些患者經過二十、三十年後,有二~三成演變成肝硬化,其中每年約有百分之五的人,會併發肝癌,因此C型肝炎病毒可說是僅次於B型肝炎的台灣肝病第二號殺手。


2020年3月1日開始. 使用健保開C肝治療藥物不設限.
病人只要確認感染慢性C肝,不論有無肝纖維化,均可成為給藥對象
參考資料: 好心肝雜誌(2020-04-15)

若病患知道自己有C肝. 但C肝抗體篩檢報告超過三年.
1. 第一次門診. 重新檢驗是否仍C肝抗體陽性. 如果仍C肝抗體陽性. 再做 RNC定量
2. 第二次門診. 因為治療前的抽血項目有 PT. 檢體不能放太久 所以需等C肝抗體和RNA>0 再來門診開立治療前的14項檢驗
3. 第三次門診開28天藥物. 當HCV基因型檢查出來之後. 聯繫病患. 再次確認病患願意吃藥治療. 聯繫廠商送藥(每周一). 確定藥品到達當天. 請病患掛門診開藥 順便開28天候抽血單.
4. 第4次門診, 開28天 藥物. 順便開下次檢驗單. 約病患回來抽血 5. 第5次門診. 治療結束後 12 周. 至門診開抽血單. 檢驗血中是否仍有HCV 病毒. 完成C肝療程(陽性機率<1/4000)

藥物使用. 以艾百樂(Maviret)為例. 每次三顆. 每天一次. 總共吃 56 天.

整個療程包括治療前抽血. 治療結束後 12 周抽血. 前後需要五個月.

其他相關資料
健保署新聞稿[110-11-29] 健保開放C肝全口服新藥處方不限科別 助攻C肝消除
yahoo新聞 C 型肝炎全口服新藥健保給付執行計畫













2023年12月6日 星期三

軟組織受傷使用冰敷已經過時?

2023-12-06 19:08
先回顧一下歷史. 冰敷是在 1978年由運動醫學醫師Gabe Mirkin提出的. 但在 2015 年 Gabe Mirkin 推翻了自己的建議.這段歷史可以參考下面兩個連結
 
參考資料1 . 下面中文是用google自動翻譯


參考資料2. 下面中文是用google自動翻譯. 裡面提到了Hyperbaric gaseous cryotherapy高壓氣體冷療法. 蠻有趣的. 順便將paper裡面表格附上.  
The R.I.C.E Protocol is a MYTH: A Review and Recommendations

摘要: 
1962 年 5 月 23 日,12 歲的埃弗雷特(埃迪)諾爾斯在馬薩諸塞州薩默維爾跳上一列貨運列車,導致他的手臂與身體完全分離。這名小男孩被送往馬薩諸塞州綜合醫院 (MGH),年輕的住院醫師羅納德·A·馬爾特 (Ronald A. Malt) 醫生試圖挽救艾迪的斷肢。儘管醫學文獻中從未記錄過重大肢體的成功再接,但 Malt 博士和 12 名醫生組成的團隊進行了歷史上首次成功的肢體再接。
On May 23, 1962, twelve- year- old Everett (Eddie) Knowles jumped on to a freight train in Somerville, MA resulting in his arm being completely severed from his body.  The young boy was taken to Massachusetts General Hospital (MGH) where Dr. Ronald A. Malt, a young chief resident, attempted to save Eddie’s detached limb.   Despite the fact that there had never been a successful reattachment of a major limb recorded in medical literature, Dr. Malt and a team of twelve doctors performed the first successful limb reattachment in history.
該行動的成功很快就成為全球現象。新聞播音員蜂擁而至,聚集在醫生團隊中,以獲取有關奇蹟般的肢體再接術的基本事實,該手術被譽為醫學史上最具有里程碑意義的手術之一。然而,手術的基本事實相當複雜,一般大眾無法理解。相反,記者將注意力集中在故事中引起讀者興趣的方面。因此,應用冰來保存切斷的組織成為故事的主要焦點。(21、33、36)
The operation’s success quickly became a global phenomenon.  Newscasters swarmed the team of doctors to obtain essential facts about the miracle limb reattachment touted as one of the most monumental operations in medical history.  However, the essential facts about the surgery were rather complicated and would not be understood by the general public.  Instead, reporters focused on the aspects of the story that would be intriguing to the reader.  As a result, the application of ice to preserve the severed tissue became the main focus of the story. (21, 33, 36)

在 1962 年 5 月 23 日事件之前,使用冰塊治療損傷從未成為醫療方案的一部分,而利用冰塊保存組織的想法很快就被全球各地的報紙報道。隨後,隨著沒有直接參與手術的個人不斷重述這個故事,事實開始改變。最終,大眾很快就接受了這樣的觀念:任何傷害都應該用冰敷來治療,無論其嚴重程度或如何發生 (36)。
The use of ice to treat injuries was never part of medical protocol prior to the events of May 23, 1962 and the notion to utilize ice for tissue preservation was quickly published by newspapers around the globe.  Subsequently, as the story was continuously retold by individuals not directly involved in the surgery, facts began to change.  Eventually, the general public was quickly accepting the notion that any injury should be treated with the application of ice, regardless of its severity or how it occurred (36).

1978年,Gabe Mirkin博士出版了《運動醫學書》,並創造了縮寫詞「RICE」(Rest、Ice、Compression、Elevation)來代表四種治療急性運動傷害的活動。四十多年來,RICE 協議已在學術課程和公眾認知中根深蒂固。然而,2013年,RICE在其著作《 Iced!》中受到了Gary Reinl的挑戰。虛幻的治療選擇。”  Reinl 引用了大量研究和解剖學資源來支持這一觀點,即在用冰緊緊包裹(壓縮)受傷部位的同時,休息並不能有效加速恢復過程,還可能導致受影響組織進一步受損。
In 1978, Dr. Gabe Mirkin released “Sportsmedicine Book” and coined the acronym “RICE” (Rest, Ice, Compression, and Elevation) to represent the four activities for treating acute athletic injuries.  The RICE protocol has been ingrained in academic curriculum as well as in public perception for over four decades.  In 2013, however, RICE was challenged by Gary Reinl in his book “Iced! The Illusionary Treatment Option.”  Reinl cited numerous studies and anatomical resources in support of the notion that resting an injury, while wrapping it tightly (compression) with ice, is ineffective in accelerating the recovery process and could also result in further damage to the affected tissues.

Reinl 的書發布後,Mirkin 在其個人網站 (31) 的 2015 年出版物中公開放棄了他對 RICE 協議的最初立場。米爾金甚至為萊因爾的第二版《 Ice d!》寫了序言。幻覺治療方案”,並對他所創造的方案提出了修改意見;
Following the release of Reinl’s book, Mirkin publicly recanted his original position on the RICE protocol in a 2015 publication on his personal website (31).  Mirkin even wrote the foreword to Reinl’s second edition of “Iced! The Illusionary Treatment Option”, and offered his revised opinion on the protocol he created;

隨後的研究表明,休息和冰敷實際上會延遲恢復。溫和的運動有助於組織更快癒合,而冷敷則可以抑制啟動並加速恢復的免疫反應。冰敷確實有助於抑制疼痛,但運動員通常更感興趣的是盡快返回比賽場地。因此,如今,RICE 並不是急性運動傷害的首選治療方法 (36)。
Subsequent research shows that rest and ice can actually delay recovery.    Mild    movement helps tissue to heal faster, and the application of cold suppresses the immune responses that start and hasten recovery. Icing does help suppress     pain, but athletes are usually far more interested in returning as quickly as possible to the playing field. So, today, RICE is not the preferred treatment for an acute athletic injury (36).

根據現有證據,唯一合理的結論是,使用 RICE 技術來加速恢復過程顯然是一個神話。2015 年,米爾金博士公開放棄了他 1978 年的最初立場,其有效性明顯受到損害。
Based upon the available evidence, the only plausible conclusion is that the use of the RICE technique to accelerate the recovery process is unequivocally a myth.  Its validity was unequivocally compromised in 2015 when Dr. Mirkin publicly recanted his original position from 1978.

有大量科學證據表明,有一些行之有效的方法可以加速肌肉、韌帶和肌腱損傷的癒合,但不包括長時間休息並結合冰敷、壓迫和抬高。為了揭穿 RICE 神話,謹慎的做法是探索對損傷的生理反應以及冰敷、壓迫、抬高和不活動對這些過程的影響。最終的結論是,有更優化的技術來加速恢復過程,其中不包括同時對受影響區域進行壓縮和局部冷卻(冰)的一段不活動期。
There is an abundance of scientific evidence purporting proven methods to accelerate the healing of muscle, ligament, and tendon injuries that do not include extended periods of rest used in conjunction with ice, compression, and elevation.  To debunk the RICE myth, it is prudent to explore the physiological responses to injury and the effect ice, compression, elevation and inactivity have on those processes.  The ultimate conclusion is that there are more optimal techniques to accelerate the recovery process that do not include a period of inactivity in which compression and topical cooling (ice) is simultaneously applied to the affected area.

Hyperbaric gaseous cryotherapy 表格的中文翻譯同樣是直接使用google翻譯. 




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