高血壓 高尿酸 慢性腎病 胰島素 https://2019medicinenote.blogspot.com/2019/12/blog-post_57.html . 糖尿病相關筆記~目錄 https://2019medicinenote.blogspot.com/2020/01/blog-post_4.html

2025年8月5日 星期二

野外與登山醫學-動物咬傷的傷口縫合考量 from uptodate

2025-08-06 10:20AM
初級縫合: 傷口經初步清理後直接縫合
延遲初級縫合: 汙染較嚴重或感染率較高的傷口, 經過清洗清創之後, 觀察數天(一般是72小時)視傷口狀況評估是否縫合
一般傷口建議12小時內縫合(臉部24小時內)
受傷超過12小時以上的傷口不建議初級縫合, 可選擇延遲初級縫合


內容來自 uptodate:Animal bites (dogs, cats, and other mammals): Evaluation and management

以下中文使用google翻譯
傷口縫合 — 對於大多數咬傷傷口未感染的患者,我們建議讓傷口保持開放,透過次級縫合而非初級縫合自行癒合(流程圖 1圖 2 )。 

對於臉部撕裂傷(包括貓咬傷)較大,影響美觀,或軀幹、手臂或腿部(不是手或腳)被狗咬傷,且傷口較大,且符合以下所有標準的患者,初級縫合是合理的選擇:

●未感染的傷口
●免疫功能正常的患者
●近期咬傷(四肢咬傷時間少於 12 小時,臉部咬傷時間少於 24 小時
●無擠壓傷或刺傷
●患肢無蜂窩性組織炎或靜脈/淋巴系統損害病史

對於可能受益於初級縫合但存在上述禁忌症之一的傷口,患者可開始預防性抗生素治療,並計劃在3-4日後進行延遲初級縫合。除非臨床醫生在延遲初級縫合方面經驗豐富,否則建議轉診至外科醫生或其他傷口專家,因為縫合時可能需要額外清創(例如,清除過多積聚的肉芽組織)。

咬傷傷口縫合方法的選擇(即初級縫合, 次級縫合或延遲初級縫合)應根據傷口性質、沖洗和清創是否能合理清潔傷口以及宿主的免疫狀態進行個體化選擇。
初級縫合可加速癒合並減少不良美容後果 [ 1,22,44,52-55 ]。然而,對於小傷口和刺傷,初級縫合可能增加的感染風險通常超過其最小的美容益處 [ 24 ]。臉部傷口是例外,因為與其他解剖部位相比,臉部傷口更有利於美容,且感染率較低 [ 1,44,49-51 ]。延遲初級縫合期間的等待期可使宿主的防禦系統減少細菌負荷,並確保不會發生感染,而感染是縫合的禁忌症。

我們同意美國傳染病學會 (IDSA) 對大多數病例的指南(例如,反對對非臉部貓咬傷進行初級縫合)[ 1 ]。然而,儘管 IDSA 不建議對非面部犬咬傷進行初級縫合,但我們同意其他專家的觀點,他們支持對軀幹、手臂或腿部(但不包括手和腳)的犬咬傷造成的撕裂傷進行初級縫合[ 46,47 ]。研究發現,初級縫合傷口不會增加此類咬傷的感染風險,反而與改善美容效果有關[ 44,46,47 ]。然而,手部傷口、刺傷或延遲出現的傷口(例如,受傷後 > 8 小時)的初級縫合與感染率增加相關[ 24,44,46 ]。

Wound closure — For most patients with uninfected bite wounds, we suggest that the wounds be left open to heal by secondary intention rather than by primary closure (algorithm 1 and figure 2). (See "Minor wound evaluation and preparation for closure", section on 'Type of closure'.)

Primary closure is a reasonable alternative in a patient with a facial laceration (including a cat bite) that is sufficiently large to affect cosmesis or a gaping dog bite on the trunk, arm, or leg (not on a hand or foot) who meets all of the following criteria:

●Uninfected wound

●Immunocompetent patient

●Recent bite (<12 hours old for bites on an extremity, <24 hours old for facial bites)

●No crush injury or puncture wound

●No prior episode of cellulitis or venous/lymphatic compromise on the affected extremity



For a wound that may benefit from primary closure but has one of these contraindications, the patient may be started on prophylactic antibiotics with a plan for delayed primary closure after three to four days. Unless the clinician has extensive experience with delayed primary closure, referral to a surgeon or other wound expert is advised since additional debridement (eg, of excessive accumulated granulation tissue) may be necessary at the time of closure. (See "Minor wound evaluation and preparation for closure", section on 'Delayed primary closure'.)

The choice of bite wound closure (ie, primary closure, healing by secondary intention, or delayed primary closure) should be individualized to the nature of the wound, whether irrigation and debridement can reasonably clean the wound, and the immune status of the host. Primary closure hastens healing and reduces adverse cosmetic outcomes [1,22,44,52-55]. However, for small wounds and puncture wounds, the potentially increased risk of infection from primary closure typically outweighs the minimal cosmetic benefit [24]. Facial wounds are an exception given increased cosmetic consequences and a lower rate of infection compared with other anatomic sites [1,44,49-51]. The waiting period during delayed primary closure permits the host defense system to decrease bacterial load and to ensure that no infection develops, which is a contraindication to closure.

We agree with the Infectious Diseases Society of American (IDSA) guidelines for most cases (eg, against primary closure of nonfacial cat bites) [1]. However, even though the IDSA recommends against primary closure of nonfacial dog bites, we agree with other experts who favor primary closure of lacerations due to dog bites on the trunk, arms, or legs (though not on the hands or feet) [46,47]. Studies have found that primary wound closure does not increase the risk of infection in such bites but is associated with improved cosmetic outcomes [44,46,47]. However, primary closure of hand wounds, puncture wounds, or wounds with delayed presentations (eg, >8 hours since injury) is associated with an increased rate of infection [24,44,46].

野外與登山醫學- 高海拔肺水腫HAPE診斷- from uptodate

相關筆記


2025-08-05 15:01
筆記
1. HAPE 通常發生在抵達高海拔之後 2-4 天
2. 乾咳, 咳痰, 咳血痰, 極度疲憊, 運動時呼吸困難 DOE , 上坡困難
    靜止時呼吸困難, 端坐呼吸
3. 有些個案會發燒(通常低於38度C)
4. 血氧濃度低於預期值 10%
5. 聽診可聽到肺部有泡泡聲(濕囉音)

下面中文使用google 翻譯
平均肺動脈壓升高(超過 35 至 40 mmHg)似乎是高海拔肺水腫 (HAPE) 的起始因素, 另一個必要因素是血管收縮不均, 某些節段性和亞節段性毛細血管床由於血管收縮相對較弱,會不成比例地暴露於升高的平均肺動脈壓所導致的微血管壓力升高(>20 mmHg)。這種血管收縮不均和局部過度灌注會導致肺泡-毛細血管屏障功能障礙和斑狀肺水腫 [ 6 ]。

(收縮明顯的區域. 血流入的少. 因肺動脈高壓引起的滲漏較少. 收縮較弱的區域. 血流進去的多. 局部肺水腫較嚴重. 但隨著時間過去. 原本收縮較弱肺水腫較嚴重區域. 局部水腫會導致該部位缺氧更嚴重. 同時肺泡被水灌滿之後也無法容納更多滲出液. 能進入的血流也會逐漸減少. 血流開始流向肺水腫較輕微的區域. 直到整個肺部都淪陷. 無法提供足夠的氧氣到腦部及全身. 腦部缺氧後會造成昏迷. 心臟缺氧之後會逐漸停止跳動. 患者死亡)

(血管收縮比較大的區域, 流入的血流會減少. 局部微血管壓力上升幅度相對較小. 因此血漿滲漏到肺泡的現象會先從血管收縮比較少的區域先開始. )

隨著肺泡毛細血管屏障破壞的進展,高分子量蛋白質、細胞和液體滲漏到肺泡腔。最終,基底內皮細胞和上皮細胞膜遭到破壞,導致肺泡出血。

HAPE 的一個顯著特徵是,隨著海拔下降或簡單地給予氧氣,由於肺血管阻力和肺動脈壓力立即下降,這個過程可以迅速逆轉。 

High mean pulmonary artery pressure, over 35 to 40 mmHg, appears to be the initiating event. However, while elevated pulmonary artery pressure is essential for HAPE, it is insufficient. The other necessary factor is uneven vasoconstriction. Specific segmental and subsegmental capillary beds with relatively less vasoconstriction are disproportionately exposed to elevated microvascular pressures (>20 mmHg) from the elevated mean pulmonary artery pressure. This uneven vasoconstriction and regional overperfusion result in failure of the alveolar-capillary barrier and patchy pulmonary edema [6].

As disruption of the alveolar-capillary barrier progresses, high molecular weight proteins, cells, and fluid leak into the alveolar space. Eventually, basement endothelial and epithelial cell membranes are disrupted, leading to alveolar hemorrhage.

A striking feature of HAPE is the rapid reversibility of this process with descent or simply the administration of oxygen, due to the immediate drop in pulmonary vascular resistance and pulmonary artery pressure.

高海拔肺水腫通常根據病史和檢查結果進行臨床診斷。
初始症狀通常在到達高海拔地區後兩到四天出現,包括輕微乾咳、運動時氣短和上坡行走困難。兒童的症狀可能更為突然。
一到兩天後,咳嗽常常轉為咳痰。
早期從運動時呼吸困難進展為靜止時呼吸困難是一個主要特徵。

重要的身體檢查發現包括心跳過速、呼吸急促、低燒(最高 38°C)和肺部濕囉音。
血氧飽和度通常比特定海拔的預期值低至少 10 個點。
吸氧和休息治療可使病情迅速好轉。
若能照胸部x光. 更有助於確診(但在野外很難做影像檢查)

(**有可能是兒童生理代償較好, 在輕度肺水腫沒有明顯症狀, 到更嚴重的程度才被觀察到異常)
(以前老師教的, 兒童血管彈性好. 在休克初期, 血管能大幅度收縮維持血壓, 到了更嚴重休克才出現突然血壓驟降. 這時候往往很難救. 不知道是不是類似情況)

DIAGNOSIS
HAPE is typically diagnosed clinically based on the history and examination findings. The initial symptoms typically begin two to four days after arrival at high altitude, including a subtle nonproductive cough, shortness of breath on exertion, and difficulty walking uphill. Symptoms can develop more precipitously in children. Over one to two days, the cough often becomes productive. Early progression from dyspnea with exertion to dyspnea at rest is a cardinal feature. Prominent examination findings include tachycardia, tachypnea, low-grade fever (up to 38°C), and pulmonary crackles. Oxygen saturation is usually at least 10 points lower than expected for a given altitude. Treatment with supplemental oxygen and rest can lead to rapid improvement. When available, characteristic findings on imaging studies help confirm the diagnosis.

CXR heart failure with bilateral pleural effusion

the same patient  2016-2026