日本研發
(不建議併用 repaglinide 及 gemfibrozil， 此兩藥併用會增加低血糖風險，在歐洲是禁止同時使用這兩種藥物。如有需要使用 fibrate 類 藥物，可以選擇將 gemfibrozil 改為 fenofibrate。)
劑量
肝臟代謝, 腎功能不良/慢性腎病/腎衰竭可使用.
eGFR 30 以下建議起始劑量 0.5mg, 可逐漸增加劑量
半衰期 1 小時
可降低餐前餐後血糖波動 , 餐前 15 分鐘服用, 或開始用餐時服用, 或開始用餐 30 分鐘內服用
作用時間短 , 相較於 SU, 低血糖風險降低, 適合慢性腎病使用, 因慢性腎病發生低血糖的風險上升
可降低餐前餐後血糖波動 , 餐前 15 分鐘服用, 或開始用餐時服用, 或開始用餐 30 分鐘內服用
作用時間短 , 相較於 SU, 低血糖風險降低, 適合慢性腎病使用, 因慢性腎病發生低血糖的風險上升
Glinides, repaglinide and nateglinide, are short acting secretagogues. The short duration of their action means reduced risk of hypoglycemia compared to sulfonylureas. This is an advantage for diabetic subjects with CKD because they belong in the high risk for hypoglycemia group as already mentioned.
Repaglinide 腸胃道吸收, 肝臟代謝(氧化及結合 glucuronic acid), 主要代謝物是 M1, M2, M4 會經由膽汁排出至糞便, 代謝物沒有降血糖的生理活性
Repaglinide 在第四第五期腎衰竭患者不用降低劑量
Repaglinide is absorbed from the gastrointestinal tract and metabolized in the liver by oxidation and conjugation with glucuronic acid. The major metabolites of repaglinide are M1, M2 and M4. These metabolites are excreted via the bile into the feces and have no hypoglycemic activity[20].
Repaglinide can be used even in CKD stages 4 and 5 without dose reduction.
Repaglinide 腸胃道吸收, 肝臟代謝(氧化及結合 glucuronic acid), 主要代謝物是 M1, M2, M4 會經由膽汁排出至糞便, 代謝物沒有降血糖的生理活性
Repaglinide 在第四第五期腎衰竭患者不用降低劑量
Repaglinide is absorbed from the gastrointestinal tract and metabolized in the liver by oxidation and conjugation with glucuronic acid. The major metabolites of repaglinide are M1, M2 and M4. These metabolites are excreted via the bile into the feces and have no hypoglycemic activity[20].
Repaglinide can be used even in CKD stages 4 and 5 without dose reduction.
沒有留言:
張貼留言