野外與登山醫學----07-Acute altitude illness WMS 2019 update AMS/HACE prevention Acetaminophen 7

Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Acute Altitude Illness: 2019 Update
統一名詞翻譯
AMS 急性高山病
HACE 高海拔腦水腫
acute altitude illness 急性高海拔疾病
Acetaminophen 乙醯胺酚, 下面用比較多人知道的"普拿疼"代替

Acetaminophen 普拿疼

acetaminophen 通常劑量是 500 mg. 但一天吃的總量沒超過 4000mg 都還算安全
分析的對象是在海拔 4370 公尺至海拔 4940 公尺這一段的健行者, 給予普拿疼 每次 1000mg, 一天三次, 對於預防AMS效果與 ibuprofen 相近
但這篇研究並沒有安慰劑對照組, 研究團隊採用過去未接受治療的健行者的發生率作為比較, 並與之前的研究, 採用相同的上升速率.
依照這些研究報告, 不建議使用普拿疼做為預防AMS的藥物,
A single study demonstrated that acetaminophen 1000 mg 3 times daily was as effective as ibuprofen at preventing AMS in trekkers travelling between 4370 and 4940 m in elevation.45 Rather than including a placebo arm, the study attempted to establish the benefit of acetaminophen by comparing the incidence rates in the study with those of untreated trekkers from prior studies that used the same ascent profile. Based on these data, acetaminophen is not recommended for use as a preventive agent over acetazolamide or dexamethasone. Recommendation. Acetaminophen should not be used for AMS prevention. Recommendation Grade: 1C