野外與登山醫學----23---WMS 2019 update HAPE PREVENTION Tadalafil 23

Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Acute Altitude Illness: 2019 Update
統一名詞翻譯
AMS 急性高山病
HACE 高海拔腦水腫
HAPE 高海拔肺水腫
acute altitude illness 急性高海拔疾病

Tadalafil
In a single, randomized placebo-controlled trial, 10 mg of tadalafil every 12 h was effective in preventing HAPE in susceptible individuals.85 The number of individuals in the study was small, and 2 developed incapacitating AMS. Clinical experience with tadalafil is lacking compared to nifedipine. As a result, further data are necessary before tadalafil can be recommended over nifedipine. Recommendation. Tadalafil can be used for HAPE prevention in known susceptible individuals who are not candidates for nifedipine. Recommendation Grade: 1C