高血壓 高尿酸 慢性腎病 胰島素 https://2019medicinenote.blogspot.com/2019/12/blog-post_57.html . 糖尿病相關筆記~目錄 https://2019medicinenote.blogspot.com/2020/01/blog-post_4.html

2023年8月8日 星期二

2023-08-09 Dexamethasone dose 不同疾病/狀態劑量選擇 高海拔疾病/氣喘/腦水腫/休克/過敏

2018-06-08 20:10
Dexamethasone dose

高海拔疾病 Altitude Sickness (Off-label) 標示外使用.
預防性使用 Prophylaxis
2 mg PO q6hr or 4 mg PO q12hr beginning on day of ascent; may be discontinued after 2- to 3-day stay at same elevation or initiation of descent
治療性使用 Treatment
急性高山病 Acute mountain sickness (AMS): 4 mg PO/IV/IM q6hr
高海拔腦水腫 High-altitude cerebral edema (HACE): 8 mg once followed by 4 mg PO/IV/IM q6hr until symptoms resolve


氣喘發作的類固醇
嚴重病患,給予 methylprednisolone 125 mg iv stat. 或者給予 dexamethasone 10mg iv stat. 給完可能要 6-12 小時才會出現作用。


Cerebral Edema 腦水腫劑量.
10 mg IV, then 4 mg IM q6hr until clinical improvement is observed; may be reduced after 2-4 days and gradually discontinued over 5-7 days



Shock 休克劑量
1-6 mg/kg IV once or 40 mg IV q2-6hr PRN
Alternative: 20 mg IV, then 3 mg/kg/day by continuous IV infusion
High-dose treatment not to be continued beyond 48-72 hours


Allergic Conditions 過敏
For control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, and serum sickness

Day 1: 4-8 mg IM 第一天可以給 4-8 mg IM.
Days 2-3: 3 mg/day PO divided q12hr
Day 4: 1.5 mg/day PO divided q12hr
Days 5-6: 0.75 mg/day PO in single daily dose 
7: No treatmen

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