Conversion from twice-daily to once-daily basal insulin

Conversion from twice-daily to once-daily basal insulin — If the patient is taking NPH or detemir twice per day and prefers once-daily basal insulin dosing, a switch to glargine or degludec once daily may be safely done by reducing the total daily basal insulin dose by 10 to 20 percent and re-titrating based on blood glucose levels. If the patient is very hyperglycemic without any hypoglycemia, the equivalent total daily dose may be given as a once-daily long-acting insulin.