即使經過適當處置，傷口感染率約 1％～12％，已經縫合的傷口，如果出現感染跡象，需重新打開，將膿瘍引流出來，以增加抗生素治療的成功率，也可以減輕不適，可適當抬高患處，尤其是發生蜂窩性組織炎時。
細菌培養結果無法立即得知（通常要 3-7 天）而且很多感染是多重菌種，經驗性抗生素需考慮環境因素和可能菌種，例如海洋環境、哺乳動物咬傷。動物咬傷或其他皮膚感染第一選擇通常是 augmentin 。
Moxifloxacin 可以用於皮膚及軟組織感染，包括動物咬傷，對 penicillin 過敏的患者，對於暴露在水環境傷口(會感染格藍氏陰性菌)是第一選擇。
其他可以選擇的抗生素包括：口服第二代或第三代頭孢素，對於巴士德類的菌種、口腔厭氧菌比第一代頭孢素、doxycycline, Baktar好。對於葡萄球菌、鏈球菌效果，跟第一代頭孢素、doxycycline, Baktar相當。
在所有情況，沒有一種單一藥物優於所有其他藥物
Wound Infections
If appropriate equipment and training are available, wounds with signs of infection after closure should be opened and any abscess collection should be drained. These maneuvers will increase the success of antibiotic treatment and will improve patient comfort. Elevation of the involved extremity may be helpful, particularly if there is a cellulitic component.131
Because culture information will not be available and many infections are likely to be polymicrobial in nature, empiric therapy is indicated with a consideration of any unique environmental issues associated with the inoculum (marine environment, mammalian bites, etc). Antimicrobial selection may also be guided practically by which items are available in the first aid kit. Amoxicillin/clavulanate is often a first choice for infected animal bites and other skin and soft tissue infections (SSTI).132, 133 Moxifloxacin is suitable for SSTI, including animal bites, in the penicillin-allergic patient and is a good first-choice agent for infections caused by aquatic exposures,134, 135 which have a higher likelihood of a gram-negative microbial etiology.136, 137
Other suitable antibiotics may include oral second- or third-generation cephalosporins. These have better activity against such relevant entities as Pasteurella spp, and oral anaerobes, and equal activity against staphylococci and streptococci compared with first-generation agents such as cephalexin, doxycycline, and trimethoprim-sulfamethoxazole. No single particular agent will be reliably effective in all scenarios. Furthermore, the data supporting the use of many antibiotics in specific clinical situations are supported less by randomized clinical trials and more by extrapolation of studies of the bacteriology of particular wounds or environments.
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